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Academic Lectures
QBE Seminar Series - Natalie Lamb (NREL) 9/4 - 11am
Department / Organization: EMP
Secure biosystems kill switch design in Saccharomyces cerevisiae informs biocontainment strategies & mechanisms of escape
The sustainable bioeconomy is dependent on the development of new technologies, which include genetically modified microorganisms for bioproduct and biofuel production. The growth of GMMs at scale raises concerns about escape from laboratory or industrial conditions and the subsequent impact on surrounding natural environments. This concern has led the NIH to release standards for the development of genetically modified microbes. Establishing secure biosystems designs is thus a critical pursuit of the industrial biotechnology community. Saccharomyces cerevisiae has been used in the food and beverage industry for hundreds of years, and more recently has been engineered to produce bioproducts and bioethanol. Here we set out to elucidate effective biocontainment design rules in S. cerevisiae that can be applied to future biocontainment strategies.
Natalie Lamb is a Postdoctoral Researcher in Synthetic Biology and Bioconversion at NREL. She completed her B.S. in Cellular & Molecular Biology at Binghamton University and her PhD in Biochemistry at the University at Buffalo. Before starting at NREL, Natalie worked as a Bioinformatician in UB Genomics and Bioinformatics Core. Her current research at NREL focuses on creating effective biocontainment strategies in Saccharomyces cerevisiae that can be applied to other industrially relevant organisms that are grown at scale.
